Today I managed to make it to the Galaxy News radio tower, where I had to see off a giant super mutant outside it, before being given a quest by Three Dog to go to a museum.
Took aaaaages to get there, mainly because I kept getting lost in the metro system. And, when I did get to the museum, I found a million super mutants waiting outside. They took some taking down!
I’ve played for about 14 hours now, although my in-game clock says 12. I know it’s more due to a few reloads I had to do because I did stuff wrong, or forgot to actually reach and “find” a location before fast-travelling away (meaning I couldn’t fast-travel back!).